Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1496 | CA4277 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 78 |
| 2 | 3TC+AZT | 4 |
| 3 | 3TC+AZT+NFV | 38 |
| 4 | D4T+DDI+IDV | 53 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A | N88D | I13V, E35D, M36I, I62V, L63P, A71V, T74S |
| >CA4277| codons 1-99 PQITLWQRPLVTVKIGGQLKEALLDTGADDTVLEDINLPGRWKPKIIGGIGGFVKVRQYD QVPIEICGHKVIGSVLVGPTPANIIGRDLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W, T215Y | K43EQ, T69N, D123E, S162C, D177E, E203EDKN, Q207E, R211K, K223Q, L228R | R172RG, I180IM |
| >CA4276| codons 1-251 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEQEGKISKIGPENPYNTPV FAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFGKQNPEIVM YQYMDDLYVGSDLEIGQHRTKINELREHLWKWGFYTPDKKHQQEPPFRWMGYELHPDKWT VQPIVLPEKDS |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |