Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4859 | CA42722 | U.S. | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+NVP | 226 |
| 2 | None | 22 |
| 3 | 3TC+AZT+NVP | 54 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | Y181C | V179DE | K20KR, K32N, V35I, T39A, K43E, K49R, V60I, R83K, K102Q, K103R, V111IM, I135K, G196GE, R211RK, L228R, R284K, T286A, V292I |
| >CA42722| codons 1-302 PISPIETVPVKLKPGMDGPRVKQWPLTEEKINALIEICAELEEEGKISRIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKQRKSVTVLDMGDAYFSVPL DKDFRKYTAFTIPSKNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIEI CQYVDDLYVGSDLEIEQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLKGAKALTEIIPLTEEAE LE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12TA, I13IV, K14R, L63P, I64V |
| >CA42721| codons 1-99 PQITLWQRPLVAVRIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |