Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5006 | CA42713 | U.S. | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+IDV | 35 |
| 2 | 3TC+AZT+SQV | 65 |
| 3 | D4T+DDI+NFV | 81 |
| 4 | APV+D4T+EFV | 84 |
| 5 | ABC+APV+D4T+DDI+RTV | 139 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32VI, I47IV, I54L, L90LM | L10F, L33F, N88D | I13V, I15IV, L19I, Y59YH, I62V, L63P, H69HQ, V77VI |
| >CA42713| codons 1-99 PQITLWQRPFVTVKVGGQIKEALLDTGADDTIFEEMNLPGRWKPKMVGGIGGFLKVRQHD QVPIEICGQKAIGTVLIGPTPVNIIGRDLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, D67N, K70R, T215F | K219Q | K101PS, K103S | E28EA, I50IT, V60I, T69N, K102KQR, K104KR, V118VI, K122E, I135T, S162CY, F214L, D218E, A272P |
| >CA42714| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTAEKIKALVEICTELEKEGKISKTGPENPYNTPI FAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLSRSRSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLFTPEQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTEEAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |