<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA4743 CA42711 U.S. 2004 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 3TC 78
2 3TC+D4T+IDV 126
3 3TC+D4T+IDV+RTV 26
4 3TC+D4T+NFV 180

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, V82A, L90M L10F, K43T L19I, M36MI, N37NS, L38LF, K55R, L63P, H69Q, A71V, I72IV  
>CA42711| codons 1-99
PQITLWQRPFVTIKIGGQIKEALLDTGADDTILEEISFPGRWTPKIIGGIGGFIRVRQYD
QIPIEICGQKVVGTVLVGPTPANIIGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T69D, K70R, M184MV, T215F D67G     T7TA, T39TA, S68G, I135T, S162Y, Q174H, Q207E, L228Q, V245VM  
>CA42712| codons 1-251
PISPIEAVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPV
FAIKKKGGDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKHNPDIVI
YQYVDDLYVGSDLEIGQHRTKIEELREHLLRWGFFTPDKKHQKEPPFQWMGYELHPDKWT
VQPIMLPEKDS

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005