Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA8404 | CA42702 | U.S. | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 9 |
| 2 | IDV | 30 |
| 3 | 3TC+AZT | 87 |
| 4 | D4T+DDI+NVP | 256 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74LV, V75T, L210W, T215Y | K219N | Y181C | V108I | K20KR, T39A, S68G, V118I, D121H, K122E, I135T, D177DE, I178IM, H221Y, V245M, A272P, L283I, I293V | P140T |
| >CA42702| codons 1-300 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPV FAIKKKDGTKWRKVTDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTILDVGDAYFSIPL HEDFRKYTAFTIPSTNNETTGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI CQYMDDLYVGSDLEIGQHRTKIEELRQHLWRWGFYTPDNKYQKEPPFLWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGTKALTEVVPLTEEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10I, V11A, T12P, I62V, L63S, I64IM, C67Y, A71V, I72IT, V77I, I93L |
| >CA42701| codons 1-99 PQITLWQRPIAPIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QVSMEIYGHKVTGTVLIGPTPVNIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |