Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1159 | CA42690 | U.S. | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 9 |
| 2 | DDI | 26 |
| 3 | D4T | 18 |
| 4 | AZT+D4T+IDV | 26 |
| 5 | AZT+DDI+NVP+RTV+SQV | 232 |
| 6 | 3TC+D4T+LPV | 74 |
| 7 | Unknown | 48 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R, M184V | K219E | Y181C | K20KR, V35L, T69N, K102M, V179I, G196E, T200A, E203K, Q207E, F214FL, L228HR, E248D, A272P, T286A, E297K |
| >CA42690| codons 1-300 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALLEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKMKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII CQYVDDLYVGSDLEIEQHRAKIKELREHLLRWGLTTPDEKHQKEPPFRWMGYELHPDKWT VQPIVLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTKEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, V82IT, I84V | T74P | L10Y, I15V, L19I, K20R, M36MI, K55N, D60E, L63PST, H69R, K70T, L89M |
| >CA42689| codons 1-99 PQITLWQRPYVTIKVGGQIREALLDTGADDTVLEEINLPGRWKPKIIGGIGGFINVRQYE QITIEICGRTAIGPVLVGPTPTNVIGRNMLTQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |