Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1293 | CA42688 | U.S. | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI | 52 |
| 2 | 3TC+D4T | 52 |
| 3 | 3TC+D4T+IDV | 52 |
| 4 | 3TC+D4T+NFV+NVP | 189 |
| 5 | 3TC+D4T+NFV | 36 |
| 6 | 3TC+AZT+NFV | 79 |
| 7 | 3TC+ABC+AZT+RTV+SQV+T20+TDF | 61 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | Y181C | V108I | V35I, K43Q, E44D, A98S, K102Q, V118I, D121C, K122E, I135T, I142V, T200A, E203K, H208Y, K223Q, L228R, Q242L, V245M, A272P, K275R, K277R, P294T | V179Q |
| >CA42688| codons 1-299 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEQDGKISKIGPENPYNTPV FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPSGLKQKKSVTILDVGDAYFSIPL CEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIQI CQYVDDLYVGSDLEIGQHRAKIKELRQYLWRWGFYTPDKKHQQEPPFRWMGYELHPDKWT VLPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVITLTEEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, V82A, I84V | L10F, L24I, L89V | M36L, N37D, R41RK, Q61E, I62V, L63P, I64M, A71I, I72T, I93L |
| >CA42687| codons 1-99 PQITLWQRPFVTIKIGGQLKEALIDTGADDTVLEELDLPGKWKPKLIGGIGGFIKVRQYD EVPMEICGHKITGTVLVGPTPANVIGRNVLTQLGCTLNF |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| R20K, D25E, S39C, L101I, G193E, V201I, L234I, S255T | D286N |
| >CA124199| codons 1-288 FLDGIDKAQEEHEKYHSNWKAMASEFNLPPVVAKEIVACCDKCQLKGEAMHGQVDCSPGI WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYFILKLAGRWPVKTIHTDNGSN FTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV FIHNFKRKGGIGEYSAGERIIDIIATDIQTKELQKQITKIQNFRVYYRDSRDPIWKGPAK LLWKGEGAVVIQDNTDIKVVPRRKAKIIRDYGKQMAGDDCVASRQNED |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |