Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1492 | CA4268 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDC | 74 |
| 2 | DDC+DDI | 61 |
| 3 | AZT+DDC | 31 |
| 4 | DDC | 104 |
| 5 | 3TC+D4T | 48 |
| 6 | 3TC+NVP | 4 |
| 7 | EFV+IDV | 22 |
| 8 | 3TC+AZT+EFV+IDV | 47 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V82A | I15V, K43R, Q61E, I62V, L63P, I72V, I93L |
| >CA4268| codons 1-99 PQITLWQRPLVTIKVGGQLKEALLDTGADDTVLEEMNLPGRWRPKMIGGIGGFIKVRQYD EVPIEICGHKAVGTVLVGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184MV, T215CY | K103N | P225PH | K20R, K49R, K101KQ, K122E, D177G, Q207E, R211K, A272P | N265NI |
| >CA4269| codons 1-290 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKEGKISRIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPGIVI YQYVDDLYVGSDLEIGQHRTKIEELREHLLKWGFYTPDKKHQKEHPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLIWASQIYPGIKVKQLCKLLRGTKALT |
References
| Author | Title | Citation |
| Kantor, R | Evolution of primary protease inhibitor resistance mutations during protease inhibitor salvage therapy. | AAC, 2002 |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |