Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4497 | CA42653 | U.S. | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 61 |
| 2 | 3TC+AZT+IDV | 44 |
| 3 | DDC+SQV | 26 |
| 4 | D4T+NFV | 70 |
| 5 | 3TC+D4T+NFV | 33 |
| 6 | ABC+AZT+NVP+RTV+SQV | 93 |
| 7 | ABC+AZT+LPV+NVP | 26 |
| 8 | 3TC+APV+LPV+TDF | 58 |
| 9 | 3TC+IDV+LPV+T20+TDF | 38 |
| 10 | 3TC+LPV+TDF | 29 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82T, I84V | L89V | L10I, V11L, I13V, I15V, K20I, E35D, M36I, N37D, D60E, L63P, K70E, A71I, Q92K |
| >CA42653| codons 1-99 PQITLWQRPILTVKVGGQLIEALLDTGADDTVLEDIDLPGRWKPKMIGGIGGFVKVRQYE QIPIEICGHEIIGTVLVGPTPTNVIGRNVLTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, T215Y | A62AV | K20KR, V35T, T39A, E44D, V118VI, K122E, I135T, K166KR, L210F, R211K, A272P, K277R, L283I, R284K, I293V |
| >CA42654| codons 1-300 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICAELEKDGKISKIGPENPYNTPV FVIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLFKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIKGTKALTEVVPLTEEAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |