<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA4497 CA42653 U.S. 2004 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 61
2 3TC+AZT+IDV 44
3 DDC+SQV 26
4 D4T+NFV 70
5 3TC+D4T+NFV 33
6 ABC+AZT+NVP+RTV+SQV 93
7 ABC+AZT+LPV+NVP 26
8 3TC+APV+LPV+TDF 58
9 3TC+IDV+LPV+T20+TDF 38
10 3TC+LPV+TDF 29

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82T, I84V L89V L10I, V11L, I13V, I15V, K20I, E35D, M36I, N37D, D60E, L63P, K70E, A71I, Q92K  
>CA42653| codons 1-99
PQITLWQRPILTVKVGGQLIEALLDTGADDTVLEDIDLPGRWKPKMIGGIGGFVKVRQYE
QIPIEICGHEIIGTVLVGPTPTNVIGRNVLTKIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, M184V, T215Y A62AV     K20KR, V35T, T39A, E44D, V118VI, K122E, I135T, K166KR, L210F, R211K, A272P, K277R, L283I, R284K, I293V  
>CA42654| codons 1-300
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICAELEKDGKISKIGPENPYNTPV
FVIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI
YQYVDDLYVGSDLEIGQHRTKIEELRQHLFKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIKGTKALTEVVPLTEEAE

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005