Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5321 | CA42652 | U.S. | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | Unknown | 52 |
| 2 | 3TC+D4T+RTV | 43 |
| 3 | 3TC+D4T+RTV | 9 |
| 4 | APV+DDI+NVP+RTV | 74 |
| 5 | APV+DDI+RTV | 43 |
| 6 | APV+DDI+NVP+RTV | 93 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K70R, L74I, M184V, T215F | D67G, K219Q | K103N, Y181C | K20R, K43N, K64H, T69N, I142V, G196E, I202V, V245K, K277R, A288S, I293V |
| >CA42652| codons 1-301 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELENEGKISKIGPENPYNTPV FAIHKKGSNRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYVDDLYVGSDLEIEQHRTKVEELRQHLLRWGFFTPDQKHQKEPPFLWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKSLTEVVPLTEEAE L |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | L10LF, K43T | K20R, M36I, Q61E, I62V, L63P, A71V, I72K |
| >CA42651| codons 1-99 PQITLWQRPFVTIKIGGQLREALLDTGADDTVLEEINLPGRWTPKMIGGIGGFVKVRQYD EVPIEICGHKVKGTVLVGPTPANIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |