<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA1466 CA42649 U.S. 2004 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 217
2 AZT+ DDI 8
3 3TC+ D4T 34
4 3TC+ D4T+ NFV 60
5 EFV+ ADV 18
6 EFV+ ADV+ NFV 13
7 EFV+ RTV+ IDV 55
8 None 9
9 3TC+ABC+IDV+RTV 113
10 Unknown 91

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, L90M G73C K20V, N37S, R41K, I62V, L63P, I64V, T74S, V77I, I93L  
>CA42649| codons 1-99
PQITLWQRPLVTIKIGGQLVEALLDTGADDTVLEEMSLPGKWKPKIIGGIGGFIKVRQYD
QVPVEICGHKAICSVLIGPTPVNIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
L74V, Y115F, M184V   K103N   E6K, K20R, V35M, K64R, D86E, K122E, I135IT, S162Y, R172K, G196K, T200I, I257L, A272P, T286A, I293V, E297K, L310I, I341IV, E344D, P345AT, K347R  
>CA42650| codons 1-351
PISPIKTVPVKLKPGMDGPRVKQWPLTEEKIKALMEICTEMEKEGKISKIGPENPYNTPV
FAIRKKDSTKWRKVVDFRELNKRTQEFWEVQLGIPHPAGLKKNKSVTVLDVGDAFFSVPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFKKQNPDIVI
YQYVDDLYVGSDLEIKQHRIKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDLQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVVPLTKEAE
LELAENREIIKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQVYQDTFRNLKT

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005