Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1490 | CA4264 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDI | 82 |
| 2 | D4T | 57 |
| 3 | 3TC+AZT | 26 |
| 4 | 3TC+AZT+IDV | 22 |
| 5 | 3TC+D4T+IDV | 35 |
| 6 | DDI+DLV+NFV | 17 |
| 7 | D4T+RTV+SQV | 37 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, V82A, L90M | K43T, F53L, L89V | L10V, I13V, I15IV, K20X, M36I, N37D, K55KR, L63P, I64IM, A71V |
| >CA4264| codons 1-99 PQITLWQRPVVTVKVGGQLXEALLDTGADDTILEEIDLPGRWTPKIIGGIGGLIRVRQYD QIPMEICGHKVIGTVLVGPTPANIIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T215Y | K219Q | K103KN, Y181C | K20R, V106I, I135V, E138EQ, G196EQ, R211T, F214L, H221Y |
| >CA4265| codons 1-265 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSITVLDVGDAYFSVPL DKDFRKYTAFTIPSVNNQTPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYMDDLYVGSDLEIQQHRTKIEELRQHLLTWGLYTPDQKYQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLN |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |