Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4323 | CA42637 | U.S. | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 87 |
| 2 | DDI | 148 |
| 3 | AZT+DDC+DLV | 83 |
| 4 | RTV+SQV | 35 |
| 5 | D4T+EFV+RTV+SQV | 31 |
| 6 | 3TC+ABC+APV+D4T | 178 |
| 7 | 3TC+ABC+APV | 67 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32VI, I54L, I84V, L90M | L10F, V11VI, L33F, Q58QE, G73GS, L89V | I13V, K20T, E35DN, M36I, R41K, D60E, I62V, L63P, C67CY, A71V, I72IM, P79H |
| >CA42637| codons 1-99 PQITLWQRPFITVKIGGQLTEALLDTGADDTIFENINLPGKWKPKMIGGIGGFLKVREYE QVPIEIYGHKVMSTVLVGHTPVNVIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, V75T, M184V, L210W, T215Y | K219D | K103N | L234I | V35IM, K43E, K64R, V118I, K122E, G196E, T200A, E203K, Q207E, D218E, F227Y, L228H, T286A, I293V, L303M | E302G |
| >CA42638| codons 1-307 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELEEEGKISKIGPENPYNTPV FAIRKKNSTKWRKITDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRAKIKELREHLWRWGFYTPEDKHQKEPPYHWMGYEIHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVVPLTEEAE LGMAENR |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |