Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA2073 | CA42632 | U.S. | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDC | 48 |
| 2 | AZT+DDC+DDI | 26 |
| 3 | D4T+DDI+SQV | 31 |
| 4 | 3TC+AZT+IDV | 43 |
| 5 | D4T+DDI+IDV | 26 |
| 6 | 3TC+AZT+IDV | 83 |
| 7 | ABC+APV+D4T+EFV | 272 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70KR, L74LI, L210W, T215Y | K219KDEN, N348I | K103N, Y181CG | V108I | E6ED, T27S, K43E, E44A, V90VI, K101KQ, V118I, K122E, I142IV, A158S, I202V, R211K, H221HY, L228R, A272P, I326V, I329V, Q334D |
| >CA42632| codons 1-352 PISPIDTVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTELEEAGKISKIGPENPYNTPV FAIKKKNSTRWRKIVDFRELNKRTQDFWEIQLGIPHPAGLQKNKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPSIFQSSMTKILEPFRKQNPDIVI GQYMDDLYVGSDLEIGQHRTKVEELRQHLWKWGFYTPDNKYQKEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPSKDLVAEVQKQGDGQWTYQIYQEPFKILKTG |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, V82A, L90M | L10I, I15V, K20I, E35ED, M36I, N37D, L63P, A71V, I93L |
| >CA42631| codons 1-99 PQITLWQRPIVTIKVGGQLIEALLDTGADDTVLEDIDLPGRWKPKLIGGIGGFIKVRQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |