Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1165 | CA42622 | U.S. | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 52 |
| 2 | DDC | 52 |
| 3 | D4T | 52 |
| 4 | 3TC+AZT+SQV | 48 |
| 5 | 3TC+AZT+NFV | 13 |
| 6 | 3TC+AZT+IDV+NVP | 20 |
| 7 | 3TC+AZT+DLV+RTV+SQV | 13 |
| 8 | 3TC+AZT | 27 |
| 9 | 3TC+AZT+EFV+SQV | 4 |
| 10 | 3TC+AZT+SQV | 18 |
| 11 | 3TC+AZT | 4 |
| 12 | None | 6 |
| 13 | 3TC+AZT+IDV+NVP+RTV | 38 |
| 14 | APV+D4T+DDI+Unknown | 6 |
| 15 | ABC+APV+D4T+RTV | 27 |
| 16 | 3TC+ABC+D4T+LPV | 114 |
| 17 | 3TC+ABC+LPV+TDF | 46 |
| 18 | Unknown | 43 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V, L210W, T215Y | A98G | K20R, E44ED, V60I, V118I, K122E, I135M, G196E, E203A, Q207E, H208Y, R211K, L228H, V245VE, A288S, I293V, E297R |
| >CA42622| codons 1-300 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPI FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIAELREYLWKWGFYTPDKKHQKEPPFHWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKSLTEVVPLTREAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I47IV, G48M, I54V, V82AS | K43T, F53FL | L10I, T12P, K14R, K20KR, E35D, M36I, N37D, L63P, C67D, A71AT |
| >CA42621| codons 1-99 PQITLWQRPIVPIRIGGQLREALLDTGADDTVLEDIDLPGRWTPKMVMGIGGLVKVRQYD QIPIEIDGHKTIGTVLVGPTPSNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |