Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1391 | CA42617 | U.S. | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 209 |
| 2 | 3TC+ADV+AZT | 39 |
| 3 | 3TC+D4T+IDV | 39 |
| 4 | 3TC+DDI+RTV+SQV | 35 |
| 5 | 3TC+EFV+NFV+SQV | 30 |
| 6 | 3TC+ABC+D4T+DDI | 61 |
| 7 | 3TC+AZT+IDV | 76 |
| 8 | 3TC+AZT+IDV+RTV | 43 |
| 9 | 3TC+AZT+LPV+TDF | 13 |
| 10 | 3TC+AZT+DDI+LPV+TDF | 36 |
| 11 | 3TC+DDI+NVP+TDF | 20 |
| 12 | 3TC+ABC+AZT+TDF | 11 |
| 13 | 3TC+ABC+AZT+LPV+TDF | 19 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G17DE, K20R, M36I, R57K, L63P |
| >CA42617| codons 1-99 PQITLWQRPLVTIKIGEQLREALLDTGADDTVLEEINLPGRWKPKMIGGIGGFIKVKQYD QIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| G190A | I50IV, K102Q, K122E, K173E, D177E, I178M, V245E, A272P, K277R |
| >CA42618| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKVGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKQKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFREQNPEMVI YQYMDDLYVASDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |