<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA4518 CA42612 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 265
2 AZT+IDV 57
3 3TC+D4T+IDV 52
4 DDI+DLV+NFV 65
5 ABC+APV+D4T+RTV 217

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L74V, L210W, T215Y K219Q Y181C   V35T, T39A, E44D, K64H, K101Q, K103R, V118I, K122E, D123E, I135V, S162D, R172K, G196E, E203D, D218E, L228H, V245T, I293V N54I
>CA42612| codons 1-300
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAELEKDGKISKIGPEIPYNTPV
FAIHKKNSTRWRKVVDFRELNKRTQDFWEVQLGIPHPAGLQKRKSVTVLDVGDAYFSIPL
DEEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFKKQNPDIVI
CQYMDDLYVGSDLEIEQHRTKIDELRQHLWRWGFYTPEQKHQKEPPFHWMGYELHPDKWT
VQPITLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, I54L, V82T, L90M V11I L10Y, I15V, L19IT, K20I, E21ED, M36I, N37D, R41K, K45R, L63P, A71V, I85V, L89LIM, Q92R  
>CA42611| codons 1-99
PQITLWQRPYITIKVGGQTIDALLDTGADDTILEEIDLPGKWKPRMIGGIGGFLKVRQYD
QIPIEICGHKVIGTVLVGPTPTNIVGRNMMTRIGCTLNF

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005
Melikian, GL Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. AAC, 2012