Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA3972 | CA42602 | U.S. | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 52 |
| 2 | 3TC+AZT+IDV | 104 |
| 3 | AZT+D4T+SQV | 87 |
| 4 | 3TC+AZT+NFV | 48 |
| 5 | 3TC+AZT+IDV+RTV | 40 |
| 6 | ABC+APV+D4T | 67 |
| 7 | 3TC+EFV+IDV+RTV | 97 |
| 8 | 3TC+AZT+TDF | 57 |
| 9 | 3TC+ATV+RTV+TDF | 27 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, M184V, L210W, T215Y | K219N | K101H | E40F, K43E, V118I, K122E, I142IV, S162C, E169D, H208Y, R211K, D218DE, V245M, I293V |
| >CA42602| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTFLEEEGKISKIGPENPYNTPV FAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLHKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILDPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQYLWKWGFYTPENKHQKEPPFLWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L90M | L10FI, V11VI, G73S, T74P | I13IV, K20I, L33LV, E35D, M36MIV, I62V, L63P, A71V, I93L |
| >CA42601| codons 1-99 PQITLWQRPIITVKIGGQLIEALLDTGADDTVVEDVNLPGRWKPKIIGGIGGFIKVRQYD QVPIEICGHKVISPVLVGPTPVNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |