Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5153 | CA42583 | U.S. | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDI | 56 |
| 2 | AZT+DDI | 17 |
| 3 | D4T | 47 |
| 4 | 3TC+D4T+IDV | 182 |
| 5 | ABC+D4T+EFV+NFV | 228 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, V82VA | E35D, N37D, K43R, L63P, V77VI, I93L |
| >CA42583| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTILEDMDLPGRWRPKIVGGIGGFIKVRQYD QIPIEICGHKAIGTVLIGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, T215F | K219Q | K103N, V106M | V60I, V118I, I135T, Q174H, V179VI, T200A, Q207R, R211E, F214L, L228R, I293V, I329IL, E344EG, Y354H, K366KR, T369TA, A376T, T386TS, K390R, A400T, T403TA, E404D, V435A, A437IV, D460N, R461K, H483HY, L491S, S519SN, A554ADNT, K558R | K540KT |
| >CA42584| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPI FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSMTVLDVGDAYFSIPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKHNPDIII YQYMDDLYVGSDLEIGQHRAKIEELRRHLLEWGLFTPDQKHQKEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAELQKQGQGQWTYQIYQGPFKNLKTGKHARMRGA HTNDVRQLAEAVQKITTESIVIWGKSPKFRLPIQKETWETWWADYWQATWIPEWEFVNTP PLVKLWYQLEKEPIAGVETFYVDGAANRETKLGKAGYVTNKGRQKVVSLTDTTNQKTELQ AIYLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKEKVYLAWVPAHT GIGGNEQVDKLVSTGIRRVL |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |