<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
IL756 IL756 Israel 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 D4T+ AZT+ IDV 49
2 AZT+ IDV+ 3TC 1

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48V, I54T, V82A   L10I, K20R, E35D, M36I, N37D, R57K, L63P, H69R, A71V, V77VI  
>IL756| codons 4-99
TLWQRPIVTIKIGGQLREALLDTGADDTVLEDIDLPGRWKPKMIVGIGGFTKVKQYDQIP
IEICGRKVIGTVLIGPTPANIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, M184V, T215F K219Q     T69TN, K102KR, D121HY, K122E, I135IV, I167IV, I178L, G196E, D218DE  
>IL756| codons 38-247
CTELEKEGKISKIGPENPYNTPVFAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHP
AGLKRKKSVTVLDVGDAYFSVPLYEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP
AIFQSSMTKVLEPFRKQNPDLVIYQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGFFTP
EQKHQKEPPFLWMGYELHPDKWTVQPIVLP

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005
Grossman, Z Mutation D30N is not preferentially selected by human immunodeficiency virus type 1 subtype C in the development of resistance to nelfinavir. AAC, 2004