Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1484 | CA4251 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDI | 152 |
| 2 | AZT+DDC | 82 |
| 3 | AZT+D4T | 26 |
| 4 | 3TC+AZT+D4T | 8 |
| 5 | 3TC+D4T+IDV | 108 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, L76V, V82A | F53FL | N37D, L63P, A71V, I93L |
| >CA4251| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKIIGGIGGLIKVRQYD QIPIEICGHKVIGTVVVGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, D67N, M184V, L210W, T215Y | K219R | E28K, K32E, E44ED, V60VI, R83K, K122E, S162Y, E169D, D177E, I178L, E204ED, R211K, A272P |
| >CA4250| codons 1-278 PISPIETVPVKLKPGMDGPKVKQWPLTKEKIEALVEICTELEKDGKISKIGPENPYNTPI FAIKKKNSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILDPFRKQNPELVI YQYVDDLYVGSDLEIGQHRTKIEDLRQHLWKWGFYTPDRKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQ |
References
| Author | Title | Citation |
| Gonzales, MJ | HIV-1 reverse transcriptase and protease subtypes: classification, amino acid mutation patterns, and prevalence in a Northern California clinic-based population. | J Infect Dis, 2001 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |