Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| IL309 | IL309b | Israel | 2001 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ AZT+ NFV | 99 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N, M46I | N88D | I13S, K20KT, L63LP, I66IF, A71AV, V77I | D25DN |
| >IL309b| codons 4-99 TLWQRPLVTSKIGGQLTEALLNTGADNTVLEEMNLPGRWKPKIIGGIGGFIKVRQYDQIP IEFCGHKVIGTVLIGPTPVNIIGRDLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V, T215FY | K49R, K122E, S134X, E169D, I178IL, I202V, E204Q, H208HY, R211Q |
| >IL309b| codons 38-247 CTEMEKEGKISRIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPXINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILDPFRKQNPDLVIYQYVDDLYVGSDLEIGQHRTKVEQLRQYLLQWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Grossman, Z | Mutation D30N is not preferentially selected by human immunodeficiency virus type 1 subtype C in the development of resistance to nelfinavir. | AAC, 2004 |