<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
IL185 IL185c Israel 2002 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 AZT+ 3TC 13
2 3TC+ NFV+ AZT 132

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
D30N   T12S, I15V, L19I, E35D, M36I, R41K, K45R, H69K, I85V, L89I, I93L, N98NI  
>IL185c| codons 9-99
PLVSIKVGGQIKEALLDTGADNTVLEDINLPGKWKPRMIGGIGGFIKVRQYDQILIEICG
KKAIGTVLVGPTPVNIVGRNILTQLGCTLIF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184V       T39E, S48T, K122E, D123G, I135L, A158S, K166R, K173A, D177E, G196K, T200A, Q207E, V245E  
>IL185c| codons 38-247
CEEMEKEGKITKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHP
AGLKKKKSVTVLDVGDAYFSVPLDEGFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSP
SIFQSSMTRILEPFRAQNPEIVIYQYVDDLYVGSDLEIKQHRAKIEELREHLLRWGFTTP
DKKHQKEPPFLWMGYELHPDKWTVQPIELP

References
Author Title Citation
Grossman, Z Mutation D30N is not preferentially selected by human immunodeficiency virus type 1 subtype C in the development of resistance to nelfinavir. AAC, 2004