<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
IL128 IL128e Israel 2000 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 3TC+ AZT 165
2 DDI+ NFV+ AZT 74

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, T215Y     Y181S T39E, E44D, V118VI, K122E, D123S, I135T, S163C, K173T, D177E, T200A, Q207E, K223KR, Y232* W153L, W239R
>IL128e| codons 38-244
CEELEKDGKISKIGPENPYNTPVFAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHP
AGLKKKKSVTVLDVGDAYFSIPLDESFRKYTAFTIPSTNNETPGIRYQYNVLPQGLKGSP
AIFQSCMTKILEPFRTQNPEIVISQYMDDLYVGSDLEIGQHRAKIEELREHLLRWGFYTP
DKKHQREPPFLWMG*ELHPDKRTVQPI

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
D30N   K14N, E35D, M36I, R41K, L63LP, H69K, L89M, I93L  
>IL128e| codons 4-99
TLWQRPLVTINIGGQLKEALLDTGADNTVLEDINLPGKWKPKMIGGIGGFIKVRQYDQIP
IEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF

References
Author Title Citation
Non-B Workgroup Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005
Grossman, Z Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration. PLoS Med, 2005