Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1271 | CA4213 | U.S. | 1997 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 52 |
| 2 | DDI | 52 |
| 3 | D4T | 100 |
| 4 | 3TC+AZT | 35 |
| 5 | 3TC+AZT+IDV | 22 |
| 6 | 3TC+D4T+IDV | 13 |
| 7 | 3TC+D4T+IDV+NVP | 4 |
| 8 | 3TC+RTV+SQV | 62 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, L90M | G73GC | E35D, M36I, N37E, R41K, L63P, K70T, V77I, I93L |
| >CA4213| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTILEDIELPGKWKPKIVGGIGGFIKVRQYD QIPIEICGHTAICTVLIGPTPVNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K219N | K20R, T39A, E44D, V118I, K122E, K126KE, I135T, D177E, H208Y, R211N, L283I, R284K, I293V | K220KR |
| >CA4214| codons 1-303 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFREYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYVDDLYVGSDLEIGQHRTKIEELRQYLWNWGFYTPDNRHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLIKGTKALTEVVPLTEEAE LEL |
References
| Author | Title | Citation |
| Shulman, NS | Efavirenz- and adefovir dipivoxil-based salvage therapy in highly treatment-experienced patients: clinical and genotypic predictors of virologic response. | JAIDS, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |