Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA17642 | CA41527 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI | 65 |
| 2 | D4T | 52 |
| 3 | 3TC+AZT+SQV | 9 |
| 4 | 3TC+AZT+IDV | 65 |
| 5 | 3TC+AZT+RTV+SQV | 39 |
| 6 | 3TC+DDI+NFV | 44 |
| 7 | ABC+DDI+EFV+NFV | 35 |
| 8 | D4T+DDI+IDV+RTV | 39 |
| 9 | 3TC+D4T+LPV | 179 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K219N | L100I, K103N | F227L, K238T | P9PS, V35L, T39A, K43Q, E44D, V60I, V118I, K122KE, I135V, S162SN, D177G, I195K, G196E, E203K, Q207E, H208Y, R211K, K223E, L228H, Q242QH, A272P, L283I, I293V |
| >CA41527| codons 1-300 PISPIETVSVKLKPGMDGPKVKQWPLTEEKIKALLEICAELEQDGKISKIGPENPYNTPI FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQNSMTKILEPFRKQNPGIVI YQYVDDLYVGSDLEKEQHRTKIKELREYLWKWGFYTPDNKHQEEPPLHWMGYELHPDTWT VHPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGTKALTEVVPLTEEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54V, L76V, I84V, L90M | K43T, G73T | L10I, I13M, E34Q, Q61R, I62V, L63P, I64V, I66V, C67F, H69R, I72V, I93L, C95V |
| >CA41526| codons 1-99 PQITLWQRPIVTMKIGGQLKEALLDTGADDTVLQEMNLPGRWTPKIVGGIGGFVKVRQYD RVPVEVFGRKAVTTVVVGPTPVNVIGRNLMTQLGVTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |