Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5481 | CA41347 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 109 |
| 2 | AZT+DDC | 65 |
| 3 | AZT+DDC+SQV | 65 |
| 4 | D4T+DDI+NFV+NVP | 4 |
| 5 | D4T+DDI+NFV | 35 |
| 6 | 3TC+AZT+IDV+RTV | 131 |
| 7 | 3TC+ABC+EFV | 48 |
| 8 | ABC+D4T+EFV | 110 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74LI, L210W, T215FY | K219Q | Y188L | K238T | K22KR, T39N, E44D, V60I, V118I, K122E, I135L, T139I, E203ED, Q207E, H208HY, D218DE, L228H, K277R |
| >CA41347| codons 1-285 PISPIETVPVKLKPGMDGPKVRQWPLTEEKIKALVEICNELEKDGKISKIGPENPYNTPI FAIKKKNSTRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSLNNEIPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLLVGSDLEIGQHRTKIDELREYLWRWGFYTPEQKHQKEPPFHWMGYELHPDTWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRG |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| N37T, P39PS, I64V, V77VI |
| >CA41346| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMTLSGRWKPKMIGGIGGFIKVRQYD QILVEICGHKAIGTVLIGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |