Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4463 | CA41334 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 22 |
| 2 | 3TC+AZT+SQV | 12 |
| 3 | D4T+DLV+NFV | 24 |
| 4 | DDC+RTV+SQV | 31 |
| 5 | D4T+DDI | 28 |
| 6 | ADV+D4T+DDI | 3 |
| 7 | ABC+ADV+APV | 40 |
| 8 | ABC+D4T+IDV+RTV | 35 |
| 9 | 3TC+AZT+IDV+RTV | 147 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I50V, I54A, V82T | L10I, K20R, E35D, M36I, N37ND, I62V, L63P, A71V, I85IV, Q92K |
| >CA41334| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDIDLPGRWKPKMIVGVGGFAKVRQYD QVPIEICGHKVIGTVLVGPTPTNIVGRNLLTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, D67N, K70R, M184V, L210LW, T215F | K219EG | K103N | D121H, K122E, D177E, G196D, Q197K, R211RK, D218E, L228LH, A272P, L283I, E297K |
| >CA41335| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL HEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYVDDLYVGSDLEIDKHRTKIEELRQHLWKWGFFTPEGKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGTKALTEVIPLTKEAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |