Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1443 | CA41328 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDI | 22 |
| 2 | DDC | 64 |
| 3 | D4T | 30 |
| 4 | D4T+IDV | 6 |
| 5 | 3TC+D4T+IDV | 79 |
| 6 | 3TC+D4T+DLV+NFV+SQV | 55 |
| 7 | 3TC+D4T+NFV+SQV | 196 |
| 8 | 3TC+ABC+APV+D4T+DDI+LPV | 61 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54IV, V82VA, I84IV | L24I, L33LF | L10I, D60DE, L63P, I64IV, A71AV, I72V, I93IL | G94GS |
| >CA41328| codons 1-99 PQITLWQRPIVTIKIGGQLKEALIDTGADDTVFEEMNLPGRWKPKLIGGIGGFVKVRQYE QIPVEICGHKVVGTVLVGPTPANVIGRNLLTQLSCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67DN, L74LV, M184V, L210LW, T215Y | K49KR, V60VI, V118VI, D123E, I135T, S162DN, D177E, V179VI, T200TA, V245E, A272S, K277R | D110DN |
| >CA41329| codons 1-280 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISRIGPENPYNTPI FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLNVGDAYFSIPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQNSMTKILEPFRKQNPEIII YQYVDDLYVGSDLEIGQHRAKIEELRQHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYSGIKVRQLC |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |