Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4374 | CA41303 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+IDV | 83 |
| 2 | D4T+NFV+NVP | 30 |
| 3 | 3TC+AZT+SQV | 22 |
| 4 | None | 48 |
| 5 | D4T+EFV+IDV+RTV | 104 |
| 6 | ABC+APV+D4T+DDI+LPV | 117 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, V75VIM, L210W, T215Y | K219E | K103KNRS, Y181C | V108VI | P4S, K11KT, T39TA, V60I, V90I, V118I, D123E, S162D, V179I, I195L, R211T, D218E, L228H, A272P, K281R, T286A, E297K | Q242QHKN |
| >CA41303| codons 1-300 PISSIETVPVTLKPGMDGPKVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKLMDFRELNKRTQDFWEIQLGIPHPAGLKKSKSVTILDVGDAYFSIPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQDSMTKILEPFRKQNPDIII CQYMDDLYVGSDLELGQHRTKIEELRQHLWTWGFYTPEEKHQKEPPFHWMGYELHPDKWT VNPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLLRGAKALTEVIPLTKEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54L, V82A, L90M | L33F, G73GACS | L10I, I13V, G16GA, E34EQ, K43S, L63P, A71T, I72IL, I93L |
| >CA41302| codons 1-99 PQITLWQRPIVTVKIAGQLKEALLDTGADDTIFQEMNLPGRWSPKIVGGIGGFLKVRQYD QIPIEICGHKTLSTVLVGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Melikian, GL | Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. | AAC, 2012 |