Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA7108 | CA41295 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDC | 117 |
| 2 | 3TC+D4T+IDV | 52 |
| 3 | 3TC+D4T+NFV+NVP | 39 |
| 4 | Unknown | 183 |
| 5 | 3TC+D4T+DDI+LPV+T20+TDF | 87 |
| 6 | 3TC+LPV+T20+TDF | 29 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74LI, M184V, L210W, T215Y | K103N, Y181C | V8I, K43N, E44D, V111I, V118I, K122E, I135T, I142IT, G196E, T200A, E203D, H208Y, R211K, H221Y, V245L, A272P, K277R, V292I, I293V, E297K |
| >CA41295| codons 1-300 PISPIETIPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELENDGKISKIGPENPYNTPV FAIKKKNSDKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDIGDAYFSIPL DEDFRKYTAFTIPSTNNETPGTRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYVDDLYVGSDLEIEQHRAKIDELRQYLWKWGFYTPDKKYQKEPPFLWMGYELHPDKWT VQPILLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEIVPLTKEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | L10F, G73T, N83D | K20R, E34Q, M36I, R41K, I62V, L63P, I64V, I93L |
| >CA41294| codons 1-99 PQITLWQRPFVTIKIGGQLREALLDTGADDTVLQEINLPGKWKPKIIGGIGGFIKVRQYD QVPVEICGHKAITTVLVGPTPVDVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |