Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4305 | CA41259 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 218 |
| 2 | 3TC+AZT | 22 |
| 3 | 3TC+AZT+RTV | 61 |
| 4 | 3TC+AZT+NVP | 48 |
| 5 | D4T+DDC+NFV | 48 |
| 6 | 3TC+D4T+EFV+IDV | 101 |
| 7 | D4T+DDI+SQV | 30 |
| 8 | 3TC+ABC+AZT+SQV | 90 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69S_GS, M184MIV, T215Y | A62V | Y181YC, G190GA | E6K, V35VL, K64R, K101Q, K122E, I135V, Y144F, T200A, E204D, L228H, A272P, I293V |
| >CA41259| codons 1-300 PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALLEICTELEKEGKISKIGPENPYNTPV FVIRKKDSSKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGIRFQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYVDDLYVASDLEIGQHRAKIEDLRQHLLRWGFYTPDKKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, G48GV, I54V, V82VA | F53FL, N88ND | L10LI, I15V, E35D, M36I, N37D, L63LP, A71AV, T74TK, V75VI |
| >CA41258| codons 1-99 PQITLWQRPIVTIKVGGQLKEALLDTGADDTVLEDIDLPGRWKPKIIVGIGGLVKVRQYD QIPIEICGHKVIGKILVGPTPANIIGRDLLTQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |