<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA1456 CA41250 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 DDC 30
2 AZT+DDC 43
3 3TC+D4T 31
4 3TC+AZT 13
5 3TC+AZT+SQV 22
6 3TC+AZT+IDV 65
7 3TC+AZT+NFV 9
8 3TC+AZT+NVP 44
9 D4T+IDV+RTV 42
10 ABC+APV+D4T+RTV+SQV 206
11 DDI+FTC+RTV+TDF+TPV 27

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46MI, I47V, I54L, I84V, L90M L33F, G73T L10I, E35D, N37S, K55KR, R57RK, L63P, I64V, I66V, H69HQ, A71V, I93L  
>CA41250| codons 1-99
PQITLWQRPIVTIKIGGQLKEALLDTGADDTIFEDMSLPGRWKPKIVGGIGGFLRVKQYD
QIPVEVCGQKVITTVLVGPTPVNVIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, L210W, T215Y K219N Y188L   V35I, T39A, K43KQ, E44D, V60I, V118I, K122E, I135T, S162C, G196GE, Q197QE, T200TA, E203K, R211K, K223E, L228R, A272P  
>CA41251| codons 1-302
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAELEQDGKISKIGPENPYNTPI
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI
YQYVDDLLVGSDLEIEEHRAKIKELRQHLWKWGFYTPDNKHQEEPPFRWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTEEAE
LE

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005