Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA7072 | CA41239 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+D4T | 44 |
| 2 | AZT+DDC+IDV | 74 |
| 3 | 3TC+D4T+RTV+SQV | 74 |
| 4 | 3TC+APV+D4T+EFV | 95 |
| 5 | 3TC+AZT+LPV+TDF | 71 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K103N | A98G | E6K, K43KQ, E44D, V118I, K122E, D123E, I135V, I142V, S162C, T200A, R211K, V245E, A272P, K277R, E297K |
| >CA41239| codons 1-300 PISPIKTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEQDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSVNNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTKEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54IMV, V82A, L90M | L33F, F53L, G73GA | L10I, T12TA, I13V, G16A, N37D, L63P, I64IV, G68GE, A71V |
| >CA41238| codons 1-99 PQITLWQRPIVAVKIAGQLKEALLDTGADDTIFEEMDLPGRWKPKIVGGIGGLVKVRQYD QIPVEICEHKVIATVLVGPTPANIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |