Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA2306 | CA41218 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | DDI | 70 |
| 2 | D4T | 35 |
| 3 | 3TC+D4T | 74 |
| 4 | 3TC+AZT+DDC+IDV | 48 |
| 5 | ADV+DLV+RTV+SQV | 54 |
| 6 | 3TC+ABC+AZT+EFV | 29 |
| 7 | ABC+D4T+DDI | 44 |
| 8 | 3TC+APV+LPV | 23 |
| 9 | None | 42 |
| 10 | 3TC+ABC+DDI+LPV | 67 |
| 11 | 3TC+AZT+LPV+TDF | 39 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82AT, I84V | Q58E | L10I, K20R, M36I, N37S, R41K, K55R, L63P |
| >CA41218| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEEISLPGKWKPKIIGGIGGFVRVREYD QIPIEICGHKAIGTVLVGPTPTNVIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K70KR, L74LI, Y115F, M184V, T215F | V35R, K102KR, K122E, I135T, S162C, A272S, P294T | I47IV |
| >CA41219| codons 1-301 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALREICTELEKEGKVSKIGPENPYNTPV FAIKKKDSTRWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKRKKSVTVLDVGDAFFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGFFTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGTKALTEVITLTEEAE L |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |