Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1263 | CA41214 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 156 |
| 2 | AZT+DDI | 52 |
| 3 | DDI | 96 |
| 4 | D4T | 9 |
| 5 | 3TC+AZT | 39 |
| 6 | 3TC+AZT+IDV | 60 |
| 7 | 3TC+AZT+RTV+SQV | 49 |
| 8 | 3TC+D4T+RTV+SQV | 46 |
| 9 | 3TC+DDI+EFV+RTV+SQV | 7 |
| 10 | 3TC+DDI+RTV+SQV | 44 |
| 11 | 3TC+DDI+RTV+SQV | 221 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | L23I, F53L, G73S | L10I, I62V, L63P, H69HY, A71T, V77I, I85V |
| >CA41214| codons 1-99 PQITLWQRPIVTIKIGGQLKEAILDTGADDTVLEEMNLPGRWKPKMIGGIGGLIKVRQYD QVPIEICGYKTISTVLIGPTPVNIVGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | T215D | K11R, K122KE, I142V, S162C, T200A, I202V, E203K, Q207E, V245I, A272P, V292VI, I293V, K311R, V314VI, F346L |
| >CA41215| codons 1-351 PISPIETVPVRLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKVKELREHLLRWGFDTPDKKHQKEPPFLWMGYELHPDKWT VQPIILPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEIVPLTEEAE LELAENREILREPIHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPLKNLKT |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |