Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA6401 | CA41206 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 70 |
| 2 | 3TC+D4T+IDV | 48 |
| 3 | 3TC+D4T+RTV+SQV | 126 |
| 4 | 3TC+AZT+EFV | 30 |
| 5 | D4T+IDV+RTV | 72 |
| 6 | DLV+EFV+LPV | 119 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, G73T | N37D, L63P, I64V, I66V, H69Y, K70R, V77I, I93L |
| >CA41206| codons 1-99 PQITLWQRPFVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKIIGGIGGFVKVRQYD QIPVEVCGYRAITTVLIGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, V75M, T215Y | K101E, Y181C, G190S | V108I | P4T, K20R, V35I, K43N, E44D, V106I, K122E, V189I, H208Y, L210E, R211K, K223Q, L228K |
| >CA41207| codons 1-300 PISTIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTELENDGKISKIGPENPYNTPV FAIKKKDSTKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLEKKKSITILDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYMDDLYISSDLEIGQHRTKIEELRQYLEKWGFYTPDKKHQQEPPFKWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVIPLTEEAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |