Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA7106 | CA41204 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+3TC | 139 |
| 2 | D4T+DDI+EFV | 44 |
| 3 | 3TC+D4T+DDI+NFV | 9 |
| 4 | 3TC+DDI+NFV | 69 |
| 5 | 3TC+DDI+NFV+RTV | 85 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N, M46I, I54L, L90M | L33F, N88D | L19LI, I62V, L63P, A71T, V77I, V82I, I93L |
| >CA41204| codons 1-99 PQITLWQRPLVTIKIGGQIKEALLDTGADNTVFEEMNLPGRWKPKIIGGIGGFLKVRQYD QVPIEICGHKTIGTVLIGPTPINIIGRDLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, T215Y | S68SN, V118I, K122KE, T200I, Q207E, R284K, I293V, P294T, E297K, E300EK, P313T | W252W*, G333EK |
| >CA41205| codons 1-361 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDNTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRIKIEELREHLLRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDS*TVNDIQKLVGKLNWASQIYAGIKVKQLCKLLKGTKALTEVVTLTKEAK LELAENREILKETVHGVYYDPSKDLIAEIQKQKQGQWTYQIYQEPFKNLKTGKYARMRGA H |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |