Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| ML_pt14 | ML136_1 | Italy | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | NA |
| 2 | AZT+DDI | 13 |
| 3 | 3TC+D4T+IDV | 13 |
| 4 | 3TC+AZT+NFV+NVP | 13 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, M184I, T215Y | K219Q | K101KE, K103KN, Y181C, G190GA | V118I, K122E, I135T, I142V, T165I, F214L, D218DE, S251Q, V292I, I293V, E297Q |
| >ML136_1| codons 1-324 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLEKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMIKILEPFRKQNPDIVI CQYIDDLYVASDLEIGQHRTKIEELRQHLLRWGLYTPEQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDQWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEIVPLTQEAE LELAENREILKEPVHGVYYDPSKD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V82A | L10I, L19IV, L38V, R41K, I62V, L63P, A71T, V77I |
| >ML136_1| codons 1-99 PQITLWQRPIVTIKIGGQIKEALLDTGADDTVLEEMNVPGKWKPKMIGGIGGFIKVRQYD QVPIEICGHKTIGTVLIGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Monno, L | Mutational patterns of paired blood and rectal biopsies in HIV-infected patients on HAART. | J Med Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |