Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| ML_pt13 | ML135 | Italy | 2002 | HIV1 | B | Rectal | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDI | NA |
| 2 | 3TC+D4T+RTV | 8 |
| 3 | 3TC+D4T+IDV+NVP | 8 |
| 4 | 3TC+DDI+IDV+NVP | 8 |
| 5 | D4T+DDI+NFV+NVP | 8 |
| 6 | ABC+SQV | 8 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V, T215F | K219E | Y181C, G190A | K20KR, T39TP, V118I, I135T, D177E, F214L | A33AP |
| >ML135| codons 1-254 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKPLVEICPEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI CQYVDDLYVASDLEIGQHRTKIEELRQHLLRWGLFTPDEKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTV |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I54V, V82A, L90LM | F53L | L10V, I15V, G16GA, M36L, L38V, P39Q, R41K, L63P, A71V, I72V |
| >ML135| codons 1-99 PQITLWQRPVVTIKVAGQLKEALLDTGADDTILEELNVQGKWKPKIIGGIGGLVKVRQYD QIPIEICGHKVVGTVLVGPTPANIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Monno, L | Mutational patterns of paired blood and rectal biopsies in HIV-infected patients on HAART. | J Med Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |