Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| ML_pt12 | ML134 | Italy | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDI | NA |
| 2 | 3TC+D4T+NVP | 17 |
| 3 | 3TC+ABC+IDV | 17 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| L210W, T215Y | Y181C | K102Q, V118I, D123E, K126KE, S134GR, I142F, S162C, M184X, G196E, R211K | R143RK |
| >ML134| codons 1-250 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKQKKSVTVLDVGDAYFSIPL DKEFREYTAFTIPGINNETPGFKYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI CQYXDDLYVGSDLEIEQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I50IV | L5LF, R57RG, I62IV, L63X, I72IV, V77VI | V56IL |
| >ML134| codons 1-99 PQITFWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGVGGFIKIGQYD QVXIEICGHKAVGTVLIGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Monno, L | Mutational patterns of paired blood and rectal biopsies in HIV-infected patients on HAART. | J Med Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |