Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| ML_pt9 | ML1030_1 | Italy | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | NA |
| 2 | AZT+DDI | 8 |
| 3 | 3TC+AZT | 8 |
| 4 | 3TC+D4T+SQV | 8 |
| 5 | 3TC+D4T+IDV | 8 |
| 6 | ABC+D4T+DDI | 8 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184MV, L210W, T215Y | E40X, R83K, K101Q, K104R, V118I, D123E, E203K, Q207E, H208HY, R211K, A272P, T286P, E297R, E312Q |
| >ML1030_1| codons 1-324 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTXLEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLQKKRSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIKELREYLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGPKALTEVIPLTREAE LELAENREILKQPVHGVYYDPSKD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, I84IV, L90M | I47IM, G73S | T4S, L10I, K20R, E35D, M36I, K45R, I62V, L63P, C67F, H69N, A71V, I72IL |
| >ML1030_1| codons 1-99 PQISLWQRPIVTIKIGGQLREALLDTGADDTVLEDINLPGRWKPRMMGGIGGFVKVRQYD QVPIEIFGNKVLSTVLVGPTPVNVIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Monno, L | Mutational patterns of paired blood and rectal biopsies in HIV-infected patients on HAART. | J Med Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |