Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| ML_pt6 | ML127_1 | Italy | 2002 | HIV1 | B | Rectal | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | NA |
| 2 | AZT+DDC | 4 |
| 3 | AZT+DDI | 8 |
| 4 | 3TC+AZT+SQV | 4 |
| 5 | 3TC+AZT+RTV | 4 |
| 6 | 3TC+D4T+IDV | 4 |
| 7 | 3TC+D4T+SQV | 8 |
| 8 | 3TC+D4T+NVP | 8 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, M184V, L210W, T215Y | K103N, Y181C | K20R, V35M, T39A, E44D, K102Q, V118I, K122E, D123E, S162A, E203K, Q207QE, H208HY, R211KN, K219X, K223KE |
| >ML127_1| codons 1-251 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICAELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKQNKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDIVI CQYVDDLYVGSDLEIGQHRTKIKELREYLWKWGFYTPDXKHQEEPPFLWMGYELHPDKWT VQPIVLPEKDS |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| N37D, L63H | G94GA, L97LS |
| >ML127_1| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD QIHIEICGHKAIGTVLVGPTPVNIIGRNLLTQIACTSNF |
References
| Author | Title | Citation |
| Monno, L | Mutational patterns of paired blood and rectal biopsies in HIV-infected patients on HAART. | J Med Virol, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |