<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
ML_pt6 ML127_1 Italy 2002 HIV1 B Rectal None

Treatment History
Order Regimen Weeks
1 AZT NA
2 AZT+DDC 4
3 AZT+DDI 8
4 3TC+AZT+SQV 4
5 3TC+AZT+RTV 4
6 3TC+D4T+IDV 4
7 3TC+D4T+SQV 8
8 3TC+D4T+NVP 8

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    N37D, L63H G94GA, L97LS
>ML127_1| codons 1-99
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD
QIHIEICGHKAIGTVLVGPTPVNIIGRNLLTQIACTSNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74I, M184V, L210W, T215Y   K103N, Y181C   K20R, V35M, T39A, E44D, K102Q, V118I, K122E, D123E, S162A, E203K, Q207QE, H208HY, R211KN, K219X, K223KE  
>ML127_1| codons 1-251
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALMEICAELEKDGKISKIGPENPYNTPV
FAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLKQNKSVTVLDVGDAYFSIPL
DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDIVI
CQYVDDLYVGSDLEIGQHRTKIKELREYLWKWGFYTPDXKHQEEPPFLWMGYELHPDKWT
VQPIVLPEKDS

References
Author Title Citation
Monno, L Mutational patterns of paired blood and rectal biopsies in HIV-infected patients on HAART. J Med Virol, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005