Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4125 | CA40820 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 64 |
| 2 | 3TC+AZT+IDV | 89 |
| 3 | NFV+NVP+SQV | 26 |
| 4 | EFV+NFV+SQV | 23 |
| 5 | 3TC+D4T+NFV+SQV | 59 |
| 6 | ABC+D4T+NFV+SQV | 35 |
| 7 | ABC+APV+D4T+RTV+SQV | 87 |
| 8 | ABC+APV+D4T+SQV | 52 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A | L10F, F53L | N37D, L63C, T74S, L89M |
| >CA40820| codons 1-99 PQITLWQRPFVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKIIGGIGGLVKVRQYD QICIEICGHKAIGSVLVGPTPANIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W, T215Y | K103NS | E6DN, A98S, K122E, D123N, Q174QK, I178IV, T200IK, Q207E, R211K, V245E, T286A, E297Q |
| >CA40821| codons 1-300 PISPINTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKSKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKKNPDVVI YQYMDDLYVGSDLEIGQHRKKIEELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIPLTQEAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |