Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1317 | CA1317-5/3 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+ DDI | NA |
| 2 | 3TC+ AZT+ DDI | NA |
| 3 | None | 3 |
| 4 | D4T+ DDI+ IDV | 53 |
| 5 | 3TC+ AZT+ SQV | 37 |
| 6 | None | 6 |
| 7 | D4T+ IDV+ NVP+ RTV | 16 |
| 8 | 3TC+ ABC+ AZT+ LPV+ SQV | 77 |
| 9 | 3TC+ EFV+ LPV+ TDF | 4 |
| 10 | None | 11 |
| 11 | TDF+ LPV+ EFV+ 3TC | 48 |
| 12 | Unknown | 16 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L90M | L10F, N88G | I13L, I15V, K20T, E35N, M36I, R41K, R57K, I62V, L63P, C67Y, A71I, I93L |
| >CA1317-5/3| codons 1-99 PQITLWQRPFVTLKVGGQLTEALLDTGADDTVLENINLPGKWKPKIIGGIGGFVKVKQYD QVPIEIYGHKIIGTVLVGPTPVNIIGRGLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| Y115F, Q151M, M184V | A62V, K70N, V75I, F77L, F116Y | K103NS, Y181C, Y188L | I31IR, E40K, K43E, K46Q, K49R, I50IV, T58N, S68G, T69TI, D121DH, K122E, P170S, Q174K, T200A, Q207E, R211K, K219T, L228H, V245T, E248D, D250E, S251D, A272P, T286A, A288S, V292I, E297K |
| >CA1317-5/3| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKRKALVEICTKMEEEGQISRVGPENPYNNPV FVIKKKDGINWRKLIDLRELNKRTQDFWEVQLGIPHPAGLKKSKSVTVLDVGDAFYSVPL HEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILESFRKKNPDIVI CQYVDDLLVGSDLEIGQHRAKIEELREHLLKWGFTTPDTKHQKEPPFHWMGYELHPDKWT VQPITLPDKEDWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKSLTEIIPLTKEAE |
References
| Author | Title | Citation |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |