Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| VC_pat257 | VC257-8 | Spain | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | D4T+ DDI+ NVP | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T215N | K103N, Y181C | I47N, R83K, T139TR, R211K, V245VM | D237H |
| >VC257-8| codons 38-246 CTEMEKEGKNSKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNERPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFNTP DKKHQKEPPFLWMGYELHPHKWTVQPIML |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I50M | K20R, Q61QE, L63P, I72V, I93M | P39QR |
| >VC257-8| codons 9-98 PLVTIKIGGQLREALLDTGADDTVLEEMNLQGRWKPKMIGGMGGFIKVRQYDEIPIEICG HKAVGTVLVGPTPVNIIGRNLLTQMGCTLN |
References
| Author | Title | Citation |
| Vidal, C | Genotypic and phenotypic resistance patterns in early-stage HIV-1-infected patients failing initial therapy with stavudine, didanosine and nevirapine. | Antivir Ther, 2002 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |