Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| VC_pat53 | VC53-11 | Spain | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | D4T+ DDI+ NVP | NA |
| 2 | AZT+DDI+NVP | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67HN, K70R | G190S | V108VI | Q145K, S162C, Q197E, E203EA, R211K, L228LR | G99W, I167F, H198HY |
| >VC53-11| codons 41-246 MEKEGKISKIGPENPYNTPVFAIKKKHSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAWL KKKKSVTILDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYKYNVLPQGWKGSPAIF QCSMTKFLEPFRKQNPDIVIYQYMDDLYVSSDLEIGEYRTKIAELRQHLLKWGFTTPDKK HQKEPPFRWMGYELHPDKWTVQPIVL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| K14KQ, L33V, I64V |
| >VC53-11| codons 6-98 WQRPLVTIQIGGQLKEALLDTGADDTVVEEMNLPGRWKPKMIGGIGGFIKVRQYDQILVE ICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLN |
References
| Author | Title | Citation |
| Vidal, C | Genotypic and phenotypic resistance patterns in early-stage HIV-1-infected patients failing initial therapy with stavudine, didanosine and nevirapine. | Antivir Ther, 2002 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |