Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1274 | CA39311 | U.S. | 2002 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 187 |
| 2 | AZT+DDC+SQV | 100 |
| 3 | 3TC+DDI | 20 |
| 4 | 3TC+D4T+IDV | 23 |
| 5 | DDC+RTV+SQV | 20 |
| 6 | AZT+DLV+NFV+SQV | 18 |
| 7 | 3TC+DDI+IDV | 23 |
| 8 | ABC+D4T+DDI+EFV | 14 |
| 9 | D4T+DDI+IDV+RTV | 95 |
| 10 | None | 84 |
| 11 | 3TC+ABC+D4T+TDF | 39 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | Q58E, G73GS | L10I, I15V, L19LP, K20IMV, M36I, I62V, L63P | D60DA |
| >CA39311| codons 1-99 PQITLWQRPIVTIKVGGQPVEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFIKVREYA QVPIEICGHKAISTVLVGPTPVNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70GR, M184MV, T215F | K219Q | K102Q, K122E, D123DN, I135V, D177E, G196E, I202V, E248ED, A272G, A288S, I293V |
| >CA39312| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKQKKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYVDDLYVGSDLEIEQHRTKVEELRQHLLRWGFFTPDQKHQKEPPFLWMGYELHPDKWT VQPIVLPDKDSWTVNDIQKLVGKLNWASQIYGGIKVKQLCKLLRGTKSLTEVVPLTEEAE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |