<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA1141 CA39291 U.S. 2001 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 D4T+DDI 17
2 3TC+AZT+IDV 27
3 3TC+D4T+DDI 9
4 3TC+D4T+IDV 21
5 3TC+DLV+RTV+SQV 53
6 3TC+D4T+RTV+SQV 33
7 3TC+D4T+DDI+IDV 142

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48M, I50V, I54V, V82T G73C L10I, I15V, K20R, M36I, N37D, I62V, L63P, A71AITV, I72E, I85V  
>CA39291| codons 1-99
PQITLWQRPIVTIKVGGQLREALLDTGADDTVLEEIDLPGRWKPKMIMGVGGFVKVRQYD
QVPIEICGHKVECTVLVGPTPTNIVGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L74I, V75T, M184V, L210W, T215Y K219N L100I, K103N   V35M, T39A, E40F, K43E, K49KR, V118I, K122KE, D177DE, G196E, R211K, D218E, V245E, A272P, I293V  
>CA39292| codons 1-300
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAFLEEEGKISRIGPENPYNTPV
FAIKKKNSDKWRKITDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI
YQYVDDLYVGSDLEIEQHRTKIEELRQHLWKWGFYTPENKHQKEPPFLWMGYELHPDKWT
VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAE

References
Author Title Citation
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005